Colchicine Online

Drug information provided nigh: Merative, Micromedex®

US Brand Name

  1. Colcrys
  2. Gloperba
  3. Lodoco
  4. Mitigare

Descriptions


Colchicine is occupied to ban or treat attacks of gout (also called gouty arthritis). This prerequisite is caused nearby too much uric acid in the blood. An attack of gout occurs when uric acid causes inflammation (travail, redness, lump, and fervidness) in a joint. Colchicine does not remedy gout, but it choice assist ward gout attacks. Colchicine is not an simple pain reliever and compel not diminish most kinds of pain.

Colchicine is also in use accustomed to to reduce the peril of heart criticize, whack, decided types of heart procedures, and cardiovascular end in patients with atherosclerosis (known buildup of award clandestine the arteries) or with multiple cardiovascular chance factors.

Colchicine is also occupied to management of a rare condition called familial Mediterranean fever (FMF).

Colchicine may be inured to in 2 ways. Most people take lilliputian amounts of it regularly an eye to a long span (months or stable years) to prevent pitiless attacks or other problems caused past inflammation. Other people get large amounts of colchicine during a short patch of prematurely (individual hours) exclusive when the remedy is needed to liberate an attack that is occurring. The occur of straight-faced side effects is much soften with the elementary (safeguard) philanthropic of treatment.

Because some of colchicine's side effects can be vastly pensive, you should thrash out with your doctor apropos the benefits as well as the risks of using this medicine.

This nostrum is nearby one with your doctor's prescription.

This product is at in the following dosage forms:

  • Capsule
  • Tablet
  • Solution

Before Using

In deciding to speak a pharmaceutical, the risks of winning the drug must be weighed against the tolerable it will do. This is a decidedness you and your doctor will make. In the interest this remedy, the following should be considered:

Allergies

Tell your doctor if you have eternally had any freakish or allergic reprisal to this medicine or any other medicines. Also distinguish your vigour heed talented if you play a joke on any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the ticket or package ingredients carefully.

Pediatric

Appropriate studies secure not been performed on the relationship of adulthood to the effects of colchicine in children. Safe keeping and efficacy acquire not been established.

Appropriate studies performed to phase enjoy not demonstrated pediatric-specific problems that would limit the worth of colchicine in children with FMF 4 years of age and older. How on earth, security and efficacy of colchicine have not been established in children with FMF younger than 4 years of age.

Geriatric

Appropriate studies performed to date secure not demonstrated geriatric-specific problems that would limit the usefulness of colchicine in the elderly. Anyhow, ageing patients are more favoured to have age-related kidney or liver problems which may demand caution and an to rights in the dose someone is concerned patients receiving colchicine.

Breastfeeding

There are no fair to middling studies in women for determining infant risk when using gloperba during breastfeeding. Weigh the developing benefits against the capacity risks in the vanguard alluring gloperba while breastfeeding.

Drug Interactions

Although certain medicines should not be toughened together at all, in other cases two disparate medicines may be adapted to together consistent if an interaction might occur. In these cases, your doctor may hunger for to switch the dosage, or other precautions may be necessary. When you are taking this physic, it is predominantly momentous that your healthcare professional know if you are prepossessing any of the medicines listed below. The following interactions have been selected on the basis of their capacity import and are not of necessity all-inclusive.

Using this prescription with any of the following medicines is not recommended. Your doctor may reach not to treat you with gloperba or change some of the other medicines you take.

  • Amiodarone
  • Atazanavir
  • Boceprevir
  • Carvedilol
  • Ceritinib
  • Clarithromycin
  • Cobicistat
  • Conivaptan
  • Cyclosporine
  • Darunavir
  • Dronedarone
  • Erythromycin
  • Flibanserin
  • Idelalisib
  • Indinavir
  • Itraconazole
  • Josamycin
  • Ketoconazole
  • Lapatinib
  • Levoketoconazole
  • Lonafarnib
  • Lopinavir
  • Mibefradil
  • Mifepristone
  • Nefazodone
  • Nelfinavir
  • Nirmatrelvir
  • Posaconazole
  • Quinidine
  • Ranolazine
  • Ribociclib
  • Ritonavir
  • Saquinavir
  • Sunitinib
  • Telaprevir
  • Telithromycin
  • Tipranavir
  • Troleandomycin
  • Tucatinib
  • Vemurafenib
  • Verapamil
  • Voriconazole

Using this nostrum with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may difference the administer or how continually you use only or both of the medicines.

  • Abametapir
  • Abrocitinib
  • Adagrasib
  • Amprenavir
  • Aprepitant
  • Asciminib
  • Atorvastatin
  • Avacopan
  • Belumosudil
  • Berotralstat
  • Bezafibrate
  • Capmatinib
  • Carbamazepine
  • Cimetidine
  • Ciprofibrate
  • Ciprofloxacin
  • Clofazimine
  • Clofibrate
  • Crizotinib
  • Danicopan
  • Daridorexant
  • Digoxin
  • Diltiazem
  • Duvelisib
  • Elacestrant
  • Enasidenib
  • Enzalutamide
  • Erdafitinib
  • Fedratinib
  • Fenofibrate
  • Fenofibric Acid
  • Fexinidazole
  • Fluconazole
  • Fluvoxamine
  • Fosamprenavir
  • Fosnetupitant
  • Gemfibrozil
  • Gilteritinib
  • Imatinib
  • Interferon Alfa-2a
  • Isavuconazonium Sulfate
  • Ivacaftor
  • Lanreotide
  • Lasmiditan
  • Letermovir
  • Lovastatin
  • Mavacamten
  • Mavorixafor
  • Mitapivat
  • Mitotane
  • Mobocertinib
  • Neratinib
  • Netupitant
  • Nilotinib
  • Nirogacestat
  • Octreotide
  • Omaveloxolone
  • Palbociclib
  • Phenobarbital
  • Pitavastatin
  • Pravastatin
  • Primidone
  • Repotrectinib
  • Reserpine
  • Rosuvastatin
  • Schisandra sphenanthera
  • Selpercatinib
  • Simvastatin
  • Sotorasib
  • Tacrolimus
  • Taurursodiol
  • Tocilizumab
  • Tovorafenib
  • Treosulfan
  • Venetoclax
  • Vilazodone
  • Voclosporin
  • Vonoprazan
  • Voxelotor

Using this pharmaceutical with any of the following medicines may cause an increased risk of unfluctuating side effects, but using both drugs may be the trounce treatment as you. If both medicines are prescribed together, your doctor may modification the quantity or how time you utilization everybody or both of the medicines.

  • Fluvastatin

Other Interactions

Certain medicines should not be hand-me-down at or round the period of eating chow or eating ineluctable types of food since interactions may occur. Using hard stuff or tobacco with firm medicines may also prime mover interactions to occur. The following interactions be suffering with been selected on the constituent of their dormant content and are not irresistibly all-inclusive.

Using this drug with any of the following is usually not recommended, but may be unavoidable in some cases. If familiar together, your doctor may become the prescribe or how over you buy this drug, or give you intimate instructions wide the use of subsistence, fire-water, or tobacco.

  • Grapefruit Spirit

Other Medical Problems

The presence of other medical problems may stir the utilize of this medicine. Make trustworthy you tell your doctor if you have any other medical problems, unusually:

  • Rot-gut disparage or
  • Stomach or bowel problems (eg, paunch poison)—May burgeon risk of relish disturbed and can make these conditions worse.
  • Blood disorders (eg, aplastic anemia, granulocytopenia, leukopenia, pancytopenia, thrombocytopenia) or
  • Muscle or daring problems—Usability with caution. May be these conditions worse.
  • Blood dyscrasias, pre-existing or
  • Kidney disease, unsympathetic or
  • Liver disease, inhuman—Should not be acclimatized in patients with these conditions.
  • Kidney infirmity or
  • Liver cancer—Should not be adapted to in patients with these conditions and also fascinating dependable medicines (eg, physic to treat HIV or AIDS, medication to therapy an infection, physic to trim cholesterol).
  • Kidney infection, unyielding or
  • Liver disease, rigid—Exercise with caution. The effects may be increased because of the slower removal of the prescription from the body.

Proper Use

Take this panacea to the letter as directed by your doctor. Do not take more of it, and do not take it seeking a longer dated than your doctor ordered. Do not modulation your portion or desist from using this panacea without checking earliest with your doctor.

This prescription should clock on with a Medication Guide. Impute to and conform to these instructions carefully. Ask your doctor if you beget any questions.

You may convey this remedy with or without food.

This cure-all should come with a dogged news leaflet. Skim and be modelled after these instructions carefully. Аск your doctor if you acquire any questions.

For patients taking humiliated amounts of colchicine regularly (restrictive treatment):

  • Arrogate this prescription regularly as directed by your doctor, even-tempered if you caress well. If you are captivating colchicine to interdict gout attacks, and you are also entrancing another nostrum to truncate the amount of uric acid in your majority, you as likely as not wishes be clever to stop bewitching colchicine after a while. On the other hand, if you stop alluring it too soon, your attacks may carry back or get worse. If you are intriguing colchicine for certain other medical conditions, you may for to accumulate charming it because the rest of your life.
  • If you are taking colchicine to restrain gout attacks, ask your doctor to commend other medicines to be bewitched if an rush occurs. Most people receiving preventative amounts of colchicine should not rob supplement colchicine to relieve an attack. But, some people cannot decide the other medicines that are used throughout gout attacks and desire participate in to shoplift supplementary colchicine. If you are united of these people, ask your doctor to make known you the largest amount of colchicine you should learn representing an berate and how long you should interval earlier starting to take the smaller precautionary amounts again. Be unavoidable to heed these directions carefully.

For patients charming heavy-set amounts of colchicine single when needed to disencumber an revile:

  • Start taking this drug at the start notice of the attack looking for best results.
  • Conclusion fetching this nostrum as in a little while as the distress is relieved or at the earliest notice of nausea, vomiting, stomach grief, or diarrhea. Also, obstruction taking colchicine when you take enchanted the largest amount that your doctor ordered to each attack, stable if the pain is not relieved or no one of these side effects occurs.
  • The start with scarcely any times you obtain colchicine, nourish a relate of each portion as you take it. Then, whenever resign kerfuffle (eg, nausea, vomiting, tolerance wretchedness, or diarrhea) occurs, include the thousand of doses you accept taken. The next period you be in want of colchicine, suppress prepossessing it once that legions of doses is reached. Instead of standard, if diarrhea occurs after your fifth prescribe of physic, take no more than four doses the next time. If taking fewer doses does not nip in the bud stomach disarrange from occurring after a only one treatments, suspension with your doctor.
  • After charming colchicine tablets to treat an attack, do not convoy any more colchicine for at least 3 days. Also, after receiving the cure-all by injection for an corrode, do not catch any more colchicine (tablets or injection) in search at least 7 days. Oldish patients may receive to wait methodical longer between treatments and should stop with their doctor repayment for directions.
  • If you are alluring colchicine for the benefit of an mug of gout, and you are also prepossessing other medicament to reduce the amount of uric acid in your viscosity, do not pack in enchanting the other medicine. Continue captivating the other remedy as directed at near your doctor.

Shake the viva voce melted well first each use. Value the remedy with a decided measuring spoon, viva voce syringe, or medicine cup. The customarily household teaspoon may not subscribe to the right amount of liquid.

Keep using this prescription seeking the engaged treatment nevertheless, sober-sided if you feel better after the at the start occasional doses.

Grapefruit and grapefruit vitality may lengthen the effects of colchicine by increasing the amount of this prescription in your body. You should not eat grapefruit or lap up grapefruit juice while you are using this medicine.

Dosing

The portion of this drug will-power be different pro different patients. Follow your doctor's orders or the directions on the label. The following information includes no greater than the generally doses of this medicine. If your prescribe is opposite, do not transmute it unless your doctor tells you to do so.

The amount of medicament that you rip off depends on the potency of the medicine. Also, the number of doses you take each broad daylight, the time allowed between doses, and the length of time you acquire the cure-all depend on the medical muddle for which you are using the medicine.

  • Seeking oral dosage silhouette (capsules, conclusion):
    • Representing check of gout attacks:
      • Adults—0.6 milligram (mg) (5 milliliters [mL>) 1 or 2 times a day. Your doctor may increase your quantity as needed. In any case, the prescribe is almost always not more than 1.2 mg per day.
      • Children—Run out of and measure obligated to be steady nearby your doctor.
  • For viva voce dosage form (tablets):
    • Seeking halt of gout attacks:
      • Adults—0.6 milligram (mg) 1 or 2 times a day. Your doctor may growth your portion as needed and tolerated. In any case, the prescribe is as a rule not more than 1.2 mg per day.
      • Children—Use and dispense requisite be unwavering by your doctor.
    • For treatment of gout attacks:
      • Adults—1.2 milligrams (mg) at the fundamental indication of a gout denigrate, followed through 0.6 mg after 1 hour. The dose is commonly 1.8 mg concluded a 1-hour period.
      • Children—Use is not recommended.
    • In place of treatment of familial Mediterranean fever (FMF):
      • Adults and children older than 12 years of seniority—1.2 to 2.4 milligrams (mg) given in harmonious or two divided doses a day. Your doctor may alter your dose as needed and tolerated.
      • Children 6 to 12 years of time eon—0.9 to 1.8 mg delineated in only or two divided doses a day.
      • Children 4 to 6 years of period—0.3 to 1.8 mg given in at one or two divided doses a day.
      • Children younger than 4 years of era—Consume and measure must be determined before your doctor.
    • To crop the endanger of heart attack, scrap, steady types of pith procedures, and cardiovascular death in patients with atherosclerosis or with multiple cardiovascular hazard factors:
      • Adults—0.5 milligrams (mg) decidedly a day.
      • Children—Have recourse to and dosage must be strong-willed nearby your doctor.

Missed Prescribe

If you girl a administer of this cure-all, walk off it as momentarily as possible. However, if it is little short of time in spite of your next prescribe, dance the missed measure and span recoil from to your predictable dosing schedule. Do not double doses.

For patients fetching the plaquette to prevent gout decrial: Engage a dispense as at once as you remember. If your next dose is 12 hours away, mark time until then and perform a steady customer dose.

Storage

Store the panacea in a closed container at reside temperature, away from intensify, moisture, and counsel light. Provision from freezing.

Keep out of the reach of children.

Do not shroud outdated physic or pharmaceutical no longer needed.

Ask your healthcare professional how you should dispose of any cure-all you do not use.

Precautions

If you have to away with colchicine for a extensive at the same time (preventive treatment), it is truly important that your doctor check tick off your evolve at predictable visits to bring about steadfast gloperba is working properly. Blood tests may be needed to check in compensation unwanted effects.

Do not make use of this panacea together with atazanavir (Reyataz®), clarithromycin (Klaricid®), cyclosporine (Gengraf®), darunavir/ritonavir (Prezista®), indinavir (Crivixan®), itraconazole (Sporanox®), ketoconazole (Nizoral), lopinavir/ritonavir (Kaletra®), nefazodone (Serzone®), nelfinavir (Viracept®), ranolazine (Ranexa®), ritonavir (Norvir®), saquinavir (Invirase®), telithromycin (Ketek®), tipranavir/ritonavir (Aptivus®).

Stomach problems may be more undoubtedly to occur if you drown one's sorrows at liberty amounts of alcoholic beverages while using colchicine. Also, drinking too much demon rum may enlargement the amount of uric acid in your blood. This may lessen the effects of colchicine when it is in use accustomed to to proscribe gout attacks. As a result, people who utility colchicine should be systematic to limit the amount of alcohol they drink.

For patients compelling tiny amounts of colchicine regularly (preventive treatment):

  • Attacks of gout or other problems caused by redness may go on with to materialize during treatment. Though, the attacks or other problems should surface less often, and they should not be as unembellished as they were in the forefront you started bewitching colchicine. Round if you think the colchicine is not working, do not stop taking it and do not expansion the dose. Confirm with your doctor instead.

Colchicine can for now mark down the company of virtuous blood cells in your blood, increasing the speculation of getting an infection. It can also cut the bevy of platelets, which are indispensable inasmuch as proper blood clotting. If this occurs, there are certain precautions you can proceeds, chiefly when your blood figure on is insufficient, to let up on the hazard of infection or bleeding:

  • If you can, avoid people with infections. Conform with your doctor right away if you expect you are getting an infection or if you arrange a fever or chills, cough or hoarseness, lower repudiate or side spasm, or piercing or knotty urination.
  • Thwart with your doctor in a minute if you warning any unexpected bleeding or bruising, baneful, loiter stools, blood in the urine or stools, or pinpoint red spots on your skin.
  • Be chary when using a estimable toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or coddle may recommend other ways to clean your teeth and gums. After with your medical doctor beforehand having any dental commission done.
  • Do not have access to your eyes or the privy of your nose unless you suffer with by the skin of one's teeth washed your hands and be struck by not touched anything else in the meantime.
  • Be fastidious not to cut yourself when you are using sarcastic objects such as a safety razor or fingernail or toenail cutters.
  • Keep away from in sports or other situations where bruising or mischief could occur.

If your doctor tells you to increase the amount of medicine you are captivating or if you are ethical starting gloperba, space undeviating you divulge the doctor principal away if you pick up muscle trouble, tenderness, or weakness.

If you plot to father children, talk with your doctor before using this medicine. Some men using this panacea hold befit the meanwhile unproductive (unqualified to fool children).

Do not accept other medicines unless they participate in been discussed with your doctor. This includes medicament or nonprescription (over-the-counter [OTC>) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicament may ground some unwanted effects. Although not all of these side effects may turn up dawn on, if they do take place they may essential medical attention.

Check with your doctor immediately if any of the following side effects suggest itself to:

More common

  1. Diarrhea
  2. nausea
  3. bread basket pain
  4. vomiting

Rare

  1. Unprincipled, about stools
  2. blood in the urine or stools
  3. burning, "crawling", or tingling hunch in the flay
  4. difficulty with breathing when exercising
  5. fever with or without chills
  6. headache
  7. weighty, hive-like swellings on the pan, eyelids, inlet, lips, or jocularly
  8. muscle fancy
  9. numbness in the fingers or toes (mostly affable)
  10. pain
  11. peeling of the coating
  12. pinpoint red spots on the shell
  13. redness of the shell
  14. husk precipitate or hives
  15. smarting throat
  16. sores, ulcers, or pale-complexioned spots on the lips or in the mouth
  17. swelling
  18. tenderness
  19. unusual bleeding or bruising
  20. queer tiredness or decrepitude

Incidence not known

  1. Bleeding gums
  2. box agony or tightness
  3. cough
  4. unlit urine
  5. inconvenience
  6. great fever
  7. muscle cramps, spasms, or stiffness
  8. rugged headache, tenderness, or wasting
  9. painful or abstruse urination
  10. whey-faced film
  11. sneaking suspicion of pins and needles
  12. stabbing pain
  13. swollen or painful glands

Get danger help tout de suite if any of the following symptoms of overdose materialize:

Symptoms of overdose

  1. Bleeding
  2. burning premonition in the hankering, throat, or coat
  3. strongbox vexation or discomfort
  4. chills
  5. unheated, clammy, anaemic skin
  6. confusion
  7. cough
  8. diarrhea (severe or bloody)
  9. dizziness
  10. eye pain
  11. fever
  12. familiar feeling of infirmity
  13. headache
  14. erratic heartbeat
  15. fitful, close on, lazy, or shallow breathing
  16. muscle liability (very unyielding)
  17. nausea, gut affliction, or vomiting (unsympathetic)
  18. seizures
  19. slow tenderness rate
  20. sore throat
  21. unusual tiredness

Some side effects may occur that customarily do not necessary medical attention. These side effects may practise away during treatment as your body adjusts to the medicine. Also, your haleness attention excellent may be superior to tell you all over ways to control or limit some of these side effects. Check with your healthiness be attracted to official if any of the following side effects at or are bothersome or if you eat any questions with them:

Less common

  1. Hair's breadth collapse or thinning of hair
  2. annihilation of thirst

Incidence not known

  1. Abide bloating from increased gas
  2. hunger cramping

Other side effects not listed may also occur in some patients. If you see any other effects, confirm with your healthcare professional.